It shouldn’t really, unless they are programs running in the background. macOS doesn’t suffer from registry overload like Windows used to
I wouldn’t worry too much - just make sure you have a good back up strategy (I personally use multiple external drives for Time Machine backups) and you’ll be fine and safe in the knowledge you can restore your system to a good state if anything bad happens (which is very rare with Macs).
I’d also recommend Little Snitch, there’s a thread about it here:
