I was writing assembly for the 6502 processor (Apple II and similar computers) back between 1993 and 1996 but truthfully, I don’t care about it at all these days.
Compilers can handle it. Plus there are some super strange gotchas a human couldn’t easily deduce, like it’s actually faster to XOR a register on itself to set it to zero, compared to just… you know, setting it zero directly?
After I stumbled upon several such dysfunctional peculiarities, I gave up.